The Development of Intelligent Lipid-Based Nanotherapeutics to be used in Cancer Treatment
Assoc. Prof. Dr. Doğa Kavaz

Assoc. Prof. Dr. Doğa Kavaz, Lecturer of the Faculty of Engineering, Cyprus International University (CIU), initiated a scientific study to develop multi-functional solid lipid delivery systems using nanotechnological approaches, one of the next generation treatment strategies for the treatment of cancer diseases.

Assoc. Prof. Dr. Kavaz said that cancer comes at the top of the list of illnesses that affect the quality of life all over the world, that ends with death. She stated that diagnosing and treatment of these diseases have not had an ideal solution yet. Assoc. Prof. Dr. Kavaz talked about the research related to new generation cancer diagnosis and treatment.

“Nanocarrier systems, which are very interesting in cancer treatment due to their unique accumulation behavior in tumor regions, increase the efficacy of the drugs used, improve the therapeutic index, decrease the toxicity of the drug, ensure the stability of the drug in the long term and increase the solubility and stability of the drug,” she said. Kavaz stated that for these reasons, lipid-based receptor-mediated nano carriers will be prepared and characterized for the use in cancer treatment as part of the project.

Kavaz pointed out that the surface properties of these particles will be examined after the preparation of nanoparticles. She announced that the nanoparticles will be activated with the model ligand to target “active” cancer cells.

Assoc. Prof. Dr. Kavaz said that anti-cancer drug nanoparticles will be loaded in the continuation of the study. Then drug profiles will be obtained and then biocompatibility tests will be conducted. Kavaz reported that at the last stage of the study, the tumor-selectivity will be targeted by targeting nanoparticles to cancerous and healthy cells. Selected anti-cancer drugs will be loaded into the carrier and they will investigate the interaction with cancer cells.

Assoc. Prof. Dr. Kavaz stated that the aim of the study was to make significant contributions to the studies in the field of receptor-based cancer treatment both scientifically and clinically. nKavaz added that the strategy for breast cancer treatment, which will be considered as a model application within the scope of this project, can be easily spread to other types of cancer.“ In addition, the nanoparticular carrier system that will be developed within the scope of the project will be easily modified and used in early cancer diagnosis in different types of cancer”, she said.

Kavaz said with the results to be obtained as part of the project, cancer, which is threatening the health of people all over the world, will be possible to treat healthy cells and tissues without damage.



Created On: June 27, 2019