Mohammed Safwan Ali Khan

Assoc. Prof. Dr. MOHAMMED SAFWAN ALI KHAN

Faculty of Pharmacy

E-mail mkhan@ciu.edu.tr
Telephone number +90 392 671 11 11
Extension 2657
Office
Other information

U.N. Sustaınable Development Goals


Good health and well-being
Climate Action

CURRICULUM VITAE

Education
  • Universiti Putra Malaysia Pharmacology and Toxicology (PhD, 2015)
  • Jawaharlal Nehru Technological University - Hyderabad Pharmaceutical Chemistry (Master, 2008)
  • Jawaharlal Nehru Technological University - Hyderabad Pharmaceutical Sciences (Undergraduate, 2006)
Publications

Articles published in other peer reviewed international journals

  • To explore pharmacological mechanism of action using digital twin. International Journal of Advanced and Applied Sciences 2022, 9, 2: 55-62. - 2022
  • Antianemia supplementation combination with vitamin C on hemoglobin levels among pregnant women in primary health care center, Jepara, Indonesia. Jurnal Farmasi Sains dan Komunitas 2021, 18, 2: 95-101. - 2021
  • Investigation of Perceived Stress and Quality of Life Assessment of pharm. D. Students at Ibn Sina National College in Saudia Arabia during 2016. Journal of Applied Pharmaceutical Science 2018, 8 (3): 82-90. - 2016
  • Gastroprotective effect of freeze dried stripped snakehead fish (Channa striata Bloch.) aqueous extract against aspirin induced ulcerogenesis in pylorus ligated rats. ISRN Pharmacology 2014, 2014, Article ID 327606: 1-8 - 2014
  • Wound healing potential of Leathery Murdah, Terminalia coriacea (Roxb) Wight & Arn. Phytopharmacology 2012, 3: 158-168. - 2012
  • Gastroprotective effect of Tabernaemontana divaricata (L.)R.Br. flower methanolic extract in rats. Pharmacologyonline 2011, 7 (2): 24-35. - 2011
  • Anti-seizure activity of Tabernaemontana divaricata (L.)R.Br. flower methanolic extract against maximal electro shock & pentylene tetrazole induced convulsions in experimental animals. Pharmacologyonline 2011, 7 (1): 784-98. - 2011
  • Anti-nociceptive effect of Terminalia coriacea (Roxb.) Wt. & Arn. leaf methanolic extract. Pharmacologyonline 2011, 7 (1): 1176-89. - 2011

Articles published in peer reviewed international journals (SCI,SSCI,Arts and Humanities)

  • Impact of Olive oil constituents on C-reactive protein: in silico evidence. Journal of Oleo Science 2022, 71, 8: 1199-1206. - 2022
  • Lung development, repair and cancer: A study on the role of MMP20 gene in adenocarcninoma. PLoS ONE 2021, 16, 4: e0250552 (1-12) - 2021
  • Lipofection of single guide RNA targeting MMP8 decreases proliferation and migration in lung adenocarcinoma cells. Medicina 2021, 57, 710. - 2021
  • Metabolic utilization of human osteoblast cell line hFOB 1.19 under normoxic and hypoxic conditions: A phenotypic microarray analysis. Experimental Biology and Medicine 2021, 0, 1-7. - 2021
  • Photoreceptor Therapy: Generation of Neurosphere-like cells from Human Mesenchymal stem cells expressing Erythropoietin. Sains Malaysiana 2020, 49, 1, 113-119. - 2020
  • Empowering Mesenchymal stem cells for Ocular Degenerative Disorders. International Journal of Molecular Sciences 2019, 20, 7, 1784: 1-13. - 2019
  • Genetically-modified human mesenchymal stem cells to express erythropoietin enhances differentiation into retinal photoreceptors: An in-vitro study. Journal of Photochemistry and Photobiology B: Biology 2019, 195: 33-38. - 2019
  • Retinal degeneration rat model: A study on the structural and functional changes in the retina following injection of sodium iodate. Journal of Photochemistry and Photobiology B: Biology 2019, 196, 111514. - 2019
  • Human mesenchymal stem cells expressing erythropoietin enhance survivability of retinal neurons against oxidative stress: An in-vitro study. Frontiers in Cellular Neuroscience 2018, 12, 190: 1-11. - 2018
  • Synthesis and in-vitro antiproliferative activity of New 1-Phenyl-3-(4-(pyridin-3-yl)phenyl)urea scaffold-based compounds. Molecules 2018, 23 (2), 297: 1-13. - 2018
  • Methanolic extract of Leathery Murdah, Terminalia coriacea {Roxb.} Wight & Arn. leaves exhibits anti-inflammatory activity in acute and chronic models. Medical Principles and Practice 2018, 27 (3), 267-271. - 2018
  • Anti-nociceptive mechanisms of flavonoids-rich methanolic leaf extract from Terminalia coriacea (Roxb.) Wight & Arn. leaves. Food and Chemical Toxicology 2018, 115, 523-531. - 2018
  • Indole alkaloids and anti-nociceptive mechanisms of Tabernaemontana divaricata (L.) R. Br. flower methanolic extract. Food and Chemical Toxicology 2018, 118, 953-962. - 2018
  • Fruit-derived Polysaccharides and Terpenoids: Recent Update on the Gastroprotective Effects and Mechanisms. Frontiers in Pharmacology 2018, 9, 569: 1-9. - 2018
  • Flavonoids and anti-oxidant activity mediated gastroprotective action of leathery murdah, Terminalia coriacea (Roxb.) Wight & Arn. leaf methanolic extract in rats. Arquivos de Gastroenterologia 2017, 54 (3): 183-191 - 2017
  • Antiulcer activity of Sandalwood (Santalum album L.) stem hydro-alcoholic extract in three gastric-ulceration models of wistar rats. Boletín Latinoamericano Y Del Caribe De Plantas Medicinales Y Aromáticas 2013, 12 (1): 81-91. - 2013
  • Prostaglandin analogous and antioxidant activity mediated gastroprotective action of Tabernaemontana divaricata (L.) R. Br. flower methanolic extract against chemically induced gastric ulcers in rats. BioMed Research International 2013, 2013, Article ID 185476: 1-18 - 2013
  • Anti-ulcer activity of Ficus religiosa stem bark ethanolic extract in rats. Journal of Medicinal Plant Research 2011, 5 (3): 354-359. - 2011

Books and books chapters published internationally

  • “Role of immunsuppressive and immunmodulatory agents in cancer” a book chapter accepted for publication in “Immunosuppression and Immunomodulation” ISBN 978-1-83768-072-6 by editor Rajeev Tyagi, to be published by IntechOpen Limited, UK. - 2022
  • “Funtional and therapeutic potential of γ-oryzanol” a book chapter in Functional Foods ISBN 978-1-83968-933-8 by editor Muhammad Sajid Arshad and published by IntechOpen Limited, UK, pages 259 - 289. - 2021

Articles published in National journals

  • Ficus dalhousiae Miq.: A rare plant specie of medicinal importance. Plant Archives 2020, 2 (20): 4227-4231. - 2020
  • Anti-epileptic activity of methanolic extract of Terminalia coriacea (Roxb.) Wight & Arn. in rats. Journal of Advances in Pharmaceutical Technology and Research 2013, 3 (2): 502-510. - 2013
  • Evaluation of the antipyretic activity of Trapa bispinosa root. Journal of Pharmacy and Chemistry 2010, 5 (1): 3-4. - 2010
  • Evaluation of the anthelmintic activity of Moringa oleifera seeds. International Journal of Pharma Professional’s Research 2010, 1 (1): 88-89. - 2010
Thesis Supervision

Doctorate Thesis Supervised

  • Anti-nociceptive mechanisms of oleuropein. Faculty of Medicine and Health Sciences, University Malaysia Sarawak, Malaysia. - 2023

Master Thesis Supervised

  • Comparative study of Clindamycin and Oxacillin sensitivity and resistance patterns in paediatrics suffering from Staphylococcal Scalded Skin Syndrome. - 2017
  • A prospective, comparative double-blind study of Sevoflurane and Thipental in inducing anaesthesia and agitation of post-operative emergence in pediatric patients. - 2017
  • A clinical study on safety efficacy and adverse drug reactions of Omalizumab added to high dose corticosteroids in asthmatic patients. - 2017
  • A pharmacoeconomic and brand study of prescriptions in an outpatient department of an hospital in Hyderabad - 2016
  • A study on prescribing patterns and drug interactions in an outpatient department of a hospital in Hyderabad - 2016
  • In-vivo mechanistic evidences of anti-nociceptive effect, isolation and characterization of three indole alkaloids from Tabernaemontana divaricata {L.} R.Br. flower methanolic extract - 2016
  • olecular mechanisms involved in the antinociceptive activity of Leathery Murdah, Terminalia coriacea {Roxb.} Wight & Arn. leaf methanolic extract, isolation and characterization of three flavonol glycosides - 2016
  • Neuropharmacological activities of Leathery Murdah, Terminalia coriacea {Roxb.} Wight & Arn. leaf methanolic extract - 2015
  • Anti-inflammatory activity of Terminalia coriacea {Roxb.} Wight & Arn. leaf methanolic extract in acute and chronic inflammatory models - 2015
  • General behavioural assessment and repeated dose 28 days sub-acute oral toxicity studies of Leathery Murdah, Terminalia coriacea {Roxb.} Wight & Arn. leaf methanolic extract in rats - 2014
  • Laxative and gut modulatory activities of Terminalia coriacea {Roxb.} Wight & Arn. leaf methanolic extract in rats - 2014
  • Anti-inflammatory activity of Terminalia coriacea {Roxb.} Wight & Arn. stem bark aqueous extract in three experimental models - 2013
  • Proximate analysis, isolation of quercetin and anti-oxidant activity of Terminalia coriacea {Roxb.} Wight & Arn. fruits - 2013
  • Anti-convulsant activity of Terminalia coriacea {Roxb.} Wight & Arn. leaf methanolic extract - 2013
Projects
  • “CRISPR-Cas targeting for Lung Cancer” Research Grant (40/G/03) funded by Center for Scientific Research, Jouf University under Ministry of Higher Education, Saudi Arabia.
  • “Dissolution of smokeless tobacco products” (Contract # HHSF223201810173P) funded by United States Food and Drug Administration Department
Awards
  • Best oral presentation at the 3rd International Anatomical and Biomedical Scientific Conferences (IABS - 2022), 22 - 24 November 2022. (2022)
  • Invited speaker at the International Conference on Ethnopharmacology and Phytochemistry - The use of native Indonesian plants containing alkaloids as an alternative treatment for Covid-19 organized and hosted by Sekolah Tinggi Ilmu Farmasi Nusaputera Semarang, sponsored by Ikatan Apoteker Indonesia, Persatuan Ahli Farmasi Indonesia and Kampus Merdeka Indonesia Jaya on 19th September 2021. (2021)
  • Research excellence award and publication incentives from Center for Scientific Research, Jouf University in 2018 for the publication in Arquivos de Gastroenterologia. (2018)
  • Judge for oral presentations at the second International Anatomical and Biomedical Scientific Conference 2017 “Research Advances in Health Sciences” held at Faculty of Medicine and Health Sciences, University Putra Malaysia, 1-2 August 2017. (2017)
  • Bronze medal at International Conference on Innovations in Pharmaceutical Sciences - 2016 organized by GNIT (JNTU-H) and sponsored by Department of Science & Technology, Govt. of India. (2016)
  • Invited speaker and judge for poster presentations at MICROBIOME - 2015 organized by Royale Degree College for Women affiliated to Osmania University on 31st December 2015. (2015)
Research Areas
  • Pharmacological evaluation of novel synthetic, marine, plant-based drugs and polyherbal formulae for anti-depressant, anti-diabetic, anti-diarrheal, anti-inflammatory, anti-nociceptive, anti-parkinsonism, anxiolytic, aphrodisiac, gastroprotective, hepatoprotective, nephroprotective, and nootropic activities.
  • Establishment of mechanisms involved in the above pharmacological activities demonstrated by the investigational agents.
  • Toxicological profiling (acute, sub-acute and chronic toxicity testing) of novel drugs in accordance with OECD guidelines.
  • Extraction, isolation, characterization and biological screening of flavonoids from Terminalia species and indole alkaloids from Tabernaemontana species.
  • Development of new in-vivo experimental models for drug evaluation.
  • Design and conduct of clinical trial to assess safety and efficacy of new drugs for plaque psoriasis.
Administrative Duties
  • Vice-Principal of Anwarul Uloom College of Pharmacy affiliated to Jawaharlal Nehru Technological University - Hyderabad (2012-2015)
  • Member of Academic Supervision Committee, College of Pharmacy, Jouf University. (2016-2018)
  • Member of Quality Unit, College of Pharmacy, Jouf University. (2016-2018)
  • Member of Blackboard Learning Management System Committee, College of Pharmacy, Jouf University. (2017-2018)