Institute of Graduate Studies and Research

Bioengineering (MSc)

Duration 2 Years
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About the Program

Program gives students an in-depth understanding of mathematics, engineering principles, physics, chemistry, physiology, and modern biology. It also aims to: train students to apply basic sciences to biological problems using engineering principles; train students to do bioengineering research and solve problems related to the design and development of diagnostic and therapeutic technologies that improve human health; and train students to apply bioengineering research to commercially viable technologies. Biotechnology Research Centre (BRC) was established to develop international projects and accelerate research and development facilities in our country. The activities of this center are in the fields of cancer biology, microbiology and environmental sciences. BRC carries out projects with international partners such as Imperial College and University of Oxford. Bioengineering M.Sc. students will be supported to take part in these projects and improve themselves. This would help them to become highly experienced scientists and would also contribute to our society in the fields of cancer, microbiology and environment.

Education Opportunities

The program is designed to educate students in using engineering principles for the analysis and manipulation of biological systems to solve problems across a spectrum of important practices. Approved technical electives are chosen by each student in consultation with his/her graduate advisor and can be selected from a range of graduate courses on mathematics, statistics, engineering, physics, biotechnology, nanotechnology, biological processes, cancer research, etc. The research methods course offered to students helps them to improve their research skills. A supervisor who is expert in his/her field is assigned for each student to assist the students in preparing their seminars and designing a study plan to ensure that students receive cohesive education with a focus on a particular bioengineering area. Students carry out their experiments in modern laboratories equipped with high technology tools and equipment.

ciu-bioengineering-phd

Career Areas

Bioengineering scientists have made countless revolutionary advances that have changed the way people live. Nowadays, about the emergence of bio-economy indicates that it is time to combine engineering principles with biology to develop new technologies. Research in bioengineering will strengthen our understanding of the basic principles of biological and environmental systems, create novel solutions to current health and environmental problems, and open new pathways for technological innovation. Bioengineering master program covers the fields of genetics, medicine and biotechnology. The program is ideal for professionals who seek greater depth in several areas of bioengineering; who wish to enhance their foundation for employment in all fields of biotechnology; and those who would like to prepare for the Ph.D. program.

Contact

Institute of Graduate Studies and Research
Graduate Sciences and Education Center, GE106
Tel: +90 392 671 1111 Extension: 2776
Institute E-mail: ciu-institute@ciu.edu.tr

Compulsory Courses

First Semester
ELECTIVE

Course code

BIOE5X1

Credit

3

Theoretical

3

Practical

0

Ects

8
ELECTIVE

Course code

BIOE5X2

Credit

3

Theoretical

3

Practical

0

Ects

8
ELECTIVE

Course code

BIOE5X3

Credit

3

Theoretical

3

Practical

0

Ects

8
ELECTIVE

Course code

BIOE5X4

Credit

3

Theoretical

3

Practical

0

Ects

8
Second Semester
THESIS

Course code

BIOE500

Credit

0

Theoretical

0

Practical

0

Ects

60
SEMINAR

Course code

BIOE590

Credit

0

Theoretical

0

Practical

0

Ects

4
ELECTIVE

Course code

BIOE5X5

Credit

3

Theoretical

3

Practical

0

Ects

8
ELECTIVE

Course code

BIOE5X6

Credit

3

Theoretical

3

Practical

0

Ects

8
ELECTIVE

Course code

BIOE5X7

Credit

3

Theoretical

3

Practical

0

Ects

8

Elective Courses

BIOPROCESS ENGINEERING

Course code

BIOE308

Credit

0

Theoretical

0

Practical

0

Ects

RESEARCH METHODS

Course code

EMNT525

Credit

3

Theoretical

3

Practical

0

Ects

0
This course is designed to be a background pass to graduate studies. The ability to formulate a research question, finding the data relevant to research questions, analyze those data, and presentation of research findings are skills that will be acquired through this course. Scientific thinking skills and methods of research, using library and online archives, experimental design, and presenting quantitative data are modules covered within the scope of this course. Scientific communication, writing research proposals, scientific reporting and thesis writing are also supported. Conference presentations, time management in research projects, ethical issues, plagiarism and skills of working in a group and networking are also highlighted throughout the semester.
BIOMEDICAL ENGINEERING AND INSTRUMENTATION

Course code

BIOE303

Credit

0

Theoretical

0

Practical

0

Ects

TECHIQUES IN MOLECULAR BIOENGINEERING

Course code

BIOE501

Credit

3

Theoretical

3

Practical

0

Ects

This course will teach principles of wet lab for molecular biology, applying them to particular cell models, and general molecular biology laboratory procedures and safety implications. Student will be introduced to PCR, gel electrophoresis, imaging, Western blotting and site-directed mutagenesis techniques.
THERMODYNAMICS

Course code

ENRE301

Credit

0

Theoretical

0

Practical

0

Ects

PHYSIOLOGY FOR ENGINEERS

Course code

BIOE513

Credit

3

Theoretical

3

Practical

0

Ects

This course will teach students to apply knowledge of mathematics, science, and engineering to cellular and systems physiology, including function, dysfunction, and the mechanisms that underlie treatment. The course will also addresses professional and ethical responsibility associated with the development, testing, and implementation (or withholding) of biomedical devices or treatments. The techniques, skills and tools necessary for engineering practice will be covered in addition to teach students to design, conduct, and analyze experiments. Topics may include the nervous system, striated and smooth muscle, and respiratory, renal, and cardiovascular systems.
TECHNIQUES IN TISSUE CULTURE AND CELLULAR BIOENGINEERING

Course code

BIOE502

Credit

3

Theoretical

3

Practical

0

Ects

This is a course will begin with introducing practical skills for the isolation of animals cells for in vitro studies, maintenance of animal cells in vitro, manipulation of animal cells in vitro, and application of molecular techniques to in vitro situations. This course also designed to bridge cell biology with engineering. At the completion of this course, the students should be able to: Discuss the molecular and cellular basis of life from an engineering perspective, identify crucial molecular parameters involved in cellular events measure and manipulate molecular parameters experimentally, apply engineering principles, concepts, and mathematical modelling in studying molecular parameters, cell structure, function, and appropriately capture the salient features of the cellular phenomena. In addition, the students should be able to manipulate the behaviour of biological cells, examine structure-function relationship and explore and criticize the existing and emerging technologies that exploit and extend our knowledge of molecular and cell biology.
BIONANOTECHNOLOGY

Course code

BIOE522

Credit

3

Theoretical

3

Practical

0

Ects

BIOTECHNOLOGY

Course code

BIOE535

Credit

3

Theoretical

3

Practical

0

Ects

ECOLOGY

Course code

BIOE526

Credit

3

Theoretical

3

Practical

0

Ects

FERMENTATION MICROBIOLOGY

Course code

BIOE531

Credit

3

Theoretical

3

Practical

0

Ects

BIOSEPERATIONS

Course code

BIOE506

Credit

3

Theoretical

3

Practical

0

Ects

In this course the separation of proteins, nucleic acids, and oligonucleotides from biological matrices is covered from analytical to process scales. Also in this course, the separation of monoclonal antibodies, which have found numerous uses as therapeutic and diagnostic agents will be covered. Analytical techniques include an interesting montage of chromatographic methods, capillary electrophoresis, isoelectric focusing, and mass spectrometry. Among separation and purification methods, liquid-liquid distribution, displacement chromatography, expanded bed adsorption, membrane chromatography, and simulated moving bed chromatography will be covered at length. Regulatory and economic considerations will be addressed, as are plant and process equipment and engineering process control. Application of DNA chip arrays, proteomics as well as evolving methodologies for a large number of drugs that are under development for treatment of cancer, AIDS, rheumatoid arthritis, and Alzheimer's disease will be discussed.
GENETIC ENGINEERING

Course code

BIOE510

Credit

3

Theoretical

3

Practical

0

Ects

The course is designed to cover the basic principles of classical and molecular genetics. Model systems for genetic analysis such as Drosophila melanogaster, Neurospora crassa, and pea and maize will be covered. The course covers a detailed description of the structure and function of nucleic acids. This includes replication and regulation with emphasis on genetic diseases, mutations, and genetic engineering and its applications, including gene therapy and genetically modified organisms, will be emphasized.
OPTICAL IMAGING TECHNIQUES

Course code

BIOE504

Credit

3

Theoretical

3

Practical

0

Ects

Students will attend lectures on the theory and underpinnings of optical imaging techniques in bioengineering, including light, fluorescent and electron microscopy and imaging. Emerging techniques such as “optogenetics” will also be covered. Practical instruction will be given in the use of light, fluorescent and electron microscopes, with samples prepared by the students.
ADVANCED TECHNIQUES OF ENVIRONMENTAL ENGINEERING ANALYSIS

Course code

ENVE528

Credit

3

Theoretical

3

Practical

0

Ects

Aims to understand the working principles of modern analytical instruments, and how they can be used to solve analytical problems encountered in environmental engineering. Includes optical methods, ultra violet, visible, infrared, X ray absorption, emission and flame spectroscopy, selective ion electrodes, mass spectroscopy, gas and liquid chromatography theory and applications, total organic carbon analyzer, electrical separation methods. Laboratory experiments.
BIOSENSORS

Course code

BIOE507

Credit

3

Theoretical

3

Practical

0

Ects

This course will cover the principles, technologies, methods and applications of biosensors and bioinstrumentation. The objective of this course is to link engineering principles to understanding of biosystems in sensors and bioelectronics. It will provide the student with detail of methods and procedures used in the design, fabrication and application of biosensors and bioelectronic devices. The fundamentals of measurement science are applied to optical, electrochemical, mass, and pressure signal transduction. Upon successful completion of this course, students are expected to be able to explain biosensing and transducing techniques, design and construct biosensors instrumentation.
PROTEING ENGINEERING

Course code

BIOE520

Credit

3

Theoretical

3

Practical

0

Ects

TISSUE ENGINEERING

Course code

BIOE512

Credit

3

Theoretical

3

Practical

0

Ects

This course will focus on the selection, processing, testing and performance of materials used in biomedical applications with special emphasis upon tissue engineering. Topics include material selection and processing, mechanisms and kinetics of material degradation, cell-material interactions and interfaces; effect of construct architecture on tissue growth; and transport through engineered tissues. Examples of engineering tissues for replacing cartilage, bone, tendons, ligaments, skin and liver will be presented. Nanotechology will also be covered.
GENERAL BIOLOGY FOR ENGINEERS

Course code

BIOE112

Credit

0

Theoretical

0

Practical

0

Ects

7
MÜHENDİSLİK İÇİN BİYOLOJİ
ADVANCED ANALYTICAL TECHNIQUES

Course code

CHEM508

Credit

3

Theoretical

3

Practical

0

Ects

GENERAL PHYSICS I

Course code

PHY101

Credit

0

Theoretical

0

Practical

0

Ects

LABORATORY APPLICATIONS IN ENVIRONMENTAL AND BIO TECHNOLOGIES

Course code

ENVE540

Credit

3

Theoretical

3

Practical

0

Ects

The course covers the topics of; general laboratory safety procedures and rules, introduction to general laboratory materials and glasswares used in environmental and biotechnology related studies, applications and operation of analytical and coarse balance and sampling techniques, application and operation of automatic pipettes, preparation of stock and diluted sample solutions and utilization of hood, applications and operations of pH-meter, applications and operations of oven, incubator and stirrer, applications and operations of centrifuge, cleaning procedures of glasswares and laboratory equipment and applications of several portable devices (Termostat, UV-visible spectrometer, Conductimeter, Turbidimeter) used in environmental and biotechnology related studies.
ADVANCED GENERAL CHEMISTRY

Course code

CHEM501

Credit

3

Theoretical

3

Practical

0

Ects

This course presents a comprehensive overview of fundamental chemistry concepts, with particular emphasis on those that are identified as competency goals in the Standard Course of Study. The course will follow an inquiry-based approach, and demonstrate the acquisition of scientific knowledge through the interpretation of experimental data. It is designed for postgraduate students who will learn types of matter, measurements, properties of substances; atoms and atomic theory, components of the atom, introduction to the periodic table, molecules and ions, formulas and naming ionic compounds, the mole, mass relations, measurements on gases, the ideal gas law, gas law calculations, stoichiometry of gaseous reactions, quantum numbers, electron configurations in atoms, polarity, principles and measurements of heat flow, calorimetry, thermo-chemical equations, enthalpies of formation.
REPRODUCTIVE BIOLOGY AND EMBRYOLOGY

Course code

BIOT512

Credit

3

Theoretical

3

Practical

0

Ects

8
This course is designed to explore the scientific principles that govern human reproduction. There will be an anatomical overview of female and male reproductive systems. There will also be a focus on menstrual and ovarian cycles, fertilization, implantation and embryonic development; development from fertilization to the blastocyst stage, implantation and placental development and embryogenesis. Reproductive disorders and abnormalities such as ectopic pregnancies, miscarriages, preterm births, fetal disorders, placental complications, parturition, and lactation are discussed, including teratology. Special topics such as infertility and the environmental causes of infertility, current assisted reproductive technologies; their development, advancement, risks, controversies and the future outlook of such technologies will be discussed. Additionally, the pathophysiology of female and male reproductive systems, in vitro fertilization and fertility medications will be explained.
FOOD BIOTECHNOLOGY

Course code

BIOT518

Credit

3

Theoretical

3

Practical

0

Ects

8
The main purpose of this course is to teach students about the principles, concepts and applications of science and technology relevant to the development of food products and end-uses for food biotechnology. Applications of modern genetics as well as an enzyme, cell, tissue, and organ-based biological processes to produce and improve foods, food ingredients, and functional foods will be discussed. Furthermore, food waste remediation and management be covered. Fundamental theory of food biotechnology will be examined including traditional fermentation applications, fermentation for food ingredients, genetic engineering in the food industry, molecular feedings and biosensory technologies for the analyses of nutrients, contaminants and toxins. Additionally, food production legislations and the ethics of food biotechnology will be presented with discussion from current literature.
CALCULUS I

Course code

MAT101

Credit

0

Theoretical

0

Practical

0

Ects

ADVANCED PHARMACOGNOSY-II

Course code

PRCO504

Credit

3

Theoretical

2

Practical

2

Ects

10
ADVANCED PHARMACOGNOSY-II
STATISTICAL METHODS IN BIO&ENVIRONMENTAL SCIENCES

Course code

ENVS541

Credit

3

Theoretical

3

Practical

0

Ects

The main topics of this course are: numerical summary statistics, graphical summary techniques, probability theory, probability distributions, mathematical expectation, special probability distributions (bernoulli, binom, poisson), probability density functions (gama, exponantial, chi-square), linear regression and correlation, excell and spss applications, sampling distributions, hypothesis testing.
STATISTICAL METHODS IN BIO&ENVIRONMENTAL SCIENCES

Course code

ENVE541

Credit

3

Theoretical

3

Practical

0

Ects

The main topics of this course are: numerical summary statistics, graphical summary techniques, probability theory, probability distributions, mathematical expectation, special probability distributions (bernoulli, binom, poisson), probability density functions (gama, exponantial, chi-square), linear regression and correlation, excell and spss applications, sampling distributions, hypothesis testing.
ENVIRONMENTAL BIOTECHNOLOGY

Course code

ENVE525

Credit

3

Theoretical

3

Practical

0

Ects

The course aim is to provide the students with information on the application of biological processes in environmental technology. Environmental biotechnology covers the use of microorganisms in biotechnological processes such as sewage and industrial wastewater treatment, solid waste degradation, soil purification, bioremediation of sites contaminated with hazardous materials, enhancement of the quality of drinking water, biodegradation, bioconversion, biorecovery, biological detoxification.
STATISTICS AND DATA ANALYSIS

Course code

BIOE505

Credit

3

Theoretical

3

Practical

0

Ects

Probability Theory: Experiments and outcomes; random variables, probability, probability density & mass functions; conditional probability, joint probability. Bayes' theorem. Standard distributions. Estimating properties of distributions: mean and variance, skewness and kurtosis. Goodness of fit of experimental data to distributions: chi-squared test, tests for normal distributions. Two populations: mixture models, t-tests, paired and unpaired. F-tests. Bonferroni correction; Analysis of variance (ANOVA). Parametric vs non-parametric statistics. Regression: Univariate and multivariate regression; significance testing on linear regression; Pearson correlation coefficient; stepwise regression; nonlinear regression. Sampling methods: Sampling from distributions, Monte-Carlo methods, bootstrapping. Time series: Notation, types of time series, simple time-series descriptors. Cross and auto-correlation. Trend removal. Linear filtering. The DFT and its applications. Inference: Bayesian methods. Decision boundaries. Bayesian and neural networks. PCA and KL transforms. MAP and ML decisions.
ADVANVED TECHNIQUES OF ENVIRONMENTAL ENGINEERING ANALYSIS

Course code

ENVS528

Credit

3

Theoretical

3

Practical

0

Ects

The course is designed to give participants a thorough training in modern environmental analytical techniques, with special regard to solving problems such as arise and it gives an introduction to the real world of environmental work while understanding the data collection process.
REMOVAL OF ORGANICS FROM WATER

Course code

ENVE513

Credit

3

Theoretical

3

Practical

0

Ects

Discusses the measurement and removal of organics such as humic substances, phenol, cresols, carbohydrates, fats, proteins, grease, surfactants, oils, pesticides, toxic and non-biodegradable soluble organics typically found in water and waste waters. Covers the removal methods such as carbon adsorption, biological treatment, chemical oxidation and advanced oxidation processes as well as the removal in natural systems.
SPECIAL TOPICS IN BIOENGINEERING I

Course code

BIOE532

Credit

3

Theoretical

3

Practical

0

Ects

ADVANCED PHARMACOGNOSY I

Course code

PRCO503

Credit

3

Theoretical

2

Practical

2

Ects

0
The plant and animal kingdom as source of drugs, General methods associated with the phytochemical investigation pf herbal products; Extraction of plant Material, separation and isolation of constituents: Sublimation, distillation, Fractional liberation, fractional chrystallization, Adsorbsion chromatography, Partition chromatagraphy, High performance liquid chromatography (HPLC), ThinLayer Chromatography(TLC), Gas-Liquid chromatography, Gel filtration chromatography, Electrochromatography, Basic metabolic pathways and the origin of secondary metabolites; Enzymes, Photosynthesis, Carbohydrate utilization, Glycosides, Fats and Fatty acids,, Aromatic biosynthesis, The shikimic acid pathway, The acetate hypothesis Amino acids biosynthesis, Peptides and proteins, Isoprenoid compounds The mevalonic acid pathway, Secondary metabolites, Stress compounds, Discovering new lead compounds in pharmaceutical research and development. Phytochemical variation within a species.
NUTRACEUTICALS

Course code

PRCO507

Credit

3

Theoretical

3

Practical

0

Ects

8
.
ADVANCED AIR POLLUTION

Course code

ENVS509

Credit

3

Theoretical

3

Practical

0

Ects

Meteorology for air pollution modelling and control; physical and thermodynamical properties of the atmosphere, equations of motion, hydrostatic equation, continuity equation, geostrophic approximation, geopotential height, thermal wind, baroclinic and barotrophic atmosphere, atmospheric stability and inversions. Air pollutant concentration models; fixed-box models, diffusion models. Control of primary particulates. Control of sulfur oxides and nitrogen oxides.
PHARMACEUTICAL TOXICOLOGY I

Course code

PHAR308

Credit

0

Theoretical

0

Practical

0

Ects

PHARMACOLOGY I

Course code

PHAR210

Credit

0

Theoretical

0

Practical

0

Ects

PLANT GROWTH REGULATORS

Course code

PSCT503

Credit

3

Theoretical

3

Practical

0

Ects

8
Plant growth substances are quite important in development and growth processes of plants. Conventional plant hormones (phytohormones); auxins, gibberellins, cytokinins, abscissic acit and ethylene are discussed in detail in this particular course. Maentime, recently accepted hormones which are known as new generation hormones as brassinostereods, jasminic acid, salicylic acid and the orhers are also discussed. Synthetic plant growth substances which are not natural hormones are also part of this course. The effects of these synthetic ones are discussed in respect to environmental concerns well as human health. Important physiological processes including germination, rooting, enlargement of fruits, fruit thinning, fruit drop, coloring, earliness, rest and dormancy, senescence, abscission, height control are discussed. Practical works with students are also included.

Students who are interested in pursuing advanced graduate studies leading to a master’s, doctoral degree, or professional doctorate degree for the Fall and Spring semesters every year. Applicants can directly apply online to our graduate programs using the application portal.

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  • Bachelor’s Degree Diploma
  • Bachelor’s Degree transcripts for each completed academic term/year.
  • Documents to prove English proficiency for English language departments,
  • Scanned copy of passport or identity card.

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Students who are interested in pursuing advanced graduate studies leading to a master’s, doctoral degree, or professional doctorate degree for the Fall and Spring semesters every year. Applicants can directly apply online to our graduate programs using the application portal.

International Applicants- Required documents;

  • Bachelor’s Degree Diploma
  • Bachelor’s Degree transcripts for each completed academic term/year.
  • Evidence of English Language competence: TOEFL (65 IBT) or IELTS (5.5). Students without these documents will take the CIU English proficiency exam on campus following arrival.
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  • CV
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